Figure 2.

Comparison of the effects of modafinil and placebo on four key electroencephalography (EEG) biomarkers during 2-h assessments over the 2 days of CPAP withdrawal. The four biomarkers were alpha/delta ratio (A), fast ratio (B), detrended fluctuation analysis (DFA) scaling exponent (C), and delta band power (D). The EEG biomarkers were average values of the eyes-open and eyes-closed states. Mixed model analyses of variance were used to test the differences at each time point. Error bars denote the 95% confidence intervals (CIs). Solid green lines, modafinil; dashed red lines, placebo. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. CPAP, continuous positive airway pressure; CI, confidence interval.