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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Synlett. 2015;26(8):1008–1025. doi: 10.1055/s-0034-1380264

Figure 5.

Figure 5

A Polyketide and Nonribosomal Peptide Molecules to be Featured in Section 4. These chemical structures represent the products of six biosynthetic pathways which have all been reconstituted in vitro. B The Basic Mechanism for Polyketide Biosynthesis. The basic steps in the catalysis of the core PKS enzymes are acyl-extender unit selection, extender unit transacylation, and chain extension. KS, ketosynthase; AT, acyltransferase; ACP, acyl carrier protein. C The Basic Mechanism for Nonribosomal Peptide Biosynthesis. The basic steps in the catalysis of the core NRPS enzymes are amino acid selection, adenylation to activate the amino acid substrate, transacylation of the amino acid, and peptide bond formation. A, adenylation domain; PCP, peptidyl carrier protein; C, condensation domain.