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(a) Key amino acid residues in the α1β1 and α1β2 interfaces and the heme-pockets of HbCO A. The α2-chain is not shown for clarity. (b) Locations of Val (blue), Leu (green), and Thr (grey) residues. The listed amino acid residues are likely to play important roles in transmitting signals during the cooperative oxygenation of Hb A. Figures were drawn according to coordinates under PDB code 2DN3. Figures were generated with the PyMOL program.61
