Fig. 1.

Recording the responses of single lumbar dorsal horn projection neurons to epidural spinal cord stimulation (SCS) in urethane-anesthesized rats. A: rats were implanted with sciatic nerve cuffs for peripheral stimulation and bipolar paddles for SCS. Peripheral stimuli [brush, press, pinch, crush (BPPC)] were applied to the hindpaw ipsilateral to the recording electrode for neuron characterization. A Pt-Ir microelectrode was lowered into the ventral aspect of the contralateral cervical spinal cord for antidromic identification of ascending projections from lumbar dorsal horn neurons. DAQ: data acquisition. B: timeline of experimental recordings: antidromic identification and neuron characterization preceded randomized blocks of SCS.