Fig. 3.

Hypocretin receptor 1 (hcrt-r1) antagonist effects on hypoglossal burst activity. A: raw and integrated traces from both genotypes perfused with normal aCSF and during exposure to 3 μM SB-408124. B: hypoglossal burst frequency, amplitude, duration, and CV IBI responses to 3 μM SB-408124 (n = 6 for each genotype) in WT and Lmx1b^f/f/p preparations. Data are means ± SE expressed as a percentage of control. *P < 0.05 indicates a statistically significant difference from control; †P < 0.05 indicates a significantly different response between genotypes (2-way RM ANOVA).