Table 2.

Time shifts between peaks for significance for QPP strength

Anesthesia	Frequency Band	Positive Peak	Nearest Negative Peak	Difference
Low-dose isoflurane	High frequency	N/A	5	N/A
Low-dose isoflurane	Infraslow	1.75	−1.5	3.25
High-dose isoflurane	High frequency	4.25	7.75	3.5
High-dose isoflurane	Infraslow	3.25	7	3.75
Dexmedetomidine	Infraslow	−1.5	−4	2.5

Columns indicate the anesthetic state, frequency band for electrophysiology, maximum significant positive peak, nearest significant negative peak to it, and the difference in time shifts between them. Rows are individual comparisons (i.e., plots in Figs. 2–4); only significant rows are shown. As anesthetic depth increases from dexmedetomidine to low-dose isoflurane to high-dose isoflurane, the difference in time shift between the peaks increases. This suggests that quasi-periodic pattern (QPP) rate decreases as anesthetic depth increases, agreeing with previous studies (Thompson et al. 2013c), but adds low-dose isoflurane as a middle point between high-dose isoflurane and dexmedetomidine. N/A, not applicable.