Fig. 5.
Autoinhibition resists G protein-regulated inward rectifier (GIRK) K+ channel and Na+-K+-ATPase blockers. A: effects of GIRK K+ channel blocker Ba2+ (100 μM, n = 7) on firing-induced Vm hyperpolarization and firing rate inhibition; ctrl, control. B: effects of Na+-K+-ATPase blocker ouabain (250 nM, n = 5/5) on firing-induced Vm hyperpolarization and firing rate inhibition. Studies in CM. *P < 0.05. Insets: traces, early and late in firing protocol. In all traces, a line marks the baseline resting Vm prior to and during stimulation.