Table I.

Summary of studies examining Tfr cell responses to antigenic challenge and in autoimmune settings

Species	Organ	Immunizing Agent	Disease	Reference
Mouse	S	SRBC, KLH Ribi		[9]
Mouse, Human	LN	KLH in CFA		[10]
Mouse	LN	OVA/alum		[11]
Mouse	LN, blood	MOG/NPOVA		[24]
Mouse	S	SRBC		[45]
Mouse	S			[80]
Mouse	S, mLN	KLH/Alum	Nephritis	[53]
Mouse	PP			[81]
Mouse	PP, SILP		Gut	[82]
Mouse	S		BXD2 arthritis	[76]
Mouse	LN	KLH/CFA	dsDNA	[57]
Human	LN			[28]
Mouse	mLN			[35]
Mouse	LN, blood, lymph	OVA/Flu/LCMV		[25]
Mouse	Ln, PP	OVA/CFA		[40]
Mouse	S, LN, PP	OVA/CFA		[41]
Mouse	S	OVA/CFA	ANA	[51]
Mouse	S		ANA, Nephritis	[43]
Mouse	S		ANA, Nephritis	[44]
Human	blood		IPEX	[79]
Human	blood		AS	[78]
Mouse	LN			[54]
Mouse	Spleen		BXD2 arthritis	[77]
Mouse	Spleen			[39]

^aAbbreviations: LN (lymph node), S (spleen), mLN (mesenteric lymph node), SILP (small intestine lamina propria), lymph (efferent lymph), SRBC (sheep red bolld cell), CFA (complete Freund’s adjuvant), Alum (aluminum hydroxide), IPEX (immunodysregulation polyendocrinopathy enteropathy X-linked), AS (ankylosing spondylitis). Blank columns indicate unimmunized (in Imm Agent column) or not associated with a specific disease (Disease column).