Fig 5.

a) Plasma concentration of DFO (continuous line) reproduced on the basis of literature pharmacokinetic data [39] for a dose of 100 mg/Kg in 24 mL, administered at a rate of 1 mL per hour for 24 hours; the concentration of chelatable iron [25] is reported as red line. b) Plasma concentration of DFO (continuous line) for a dose of 100 mg/Kg in 12 mL, administered at a rate of 1 mL per hour for 12 hours. The concentration of chelatable iron [25], reported as red line, takes into account its increase when DFO is not administered.