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. 2015 Jul 20;10(7):e0133404. doi: 10.1371/journal.pone.0133404

Table 2. Results for gene-based test and dynamic module search of three schizophrenia GWAS datasets.

GWAS datasets MGS Affy6 Affy500K
No. of genes Total genes 27,188 26,899 23,420
Genes in PPI 11,456 11,362 10,232
Genes in PPI and P-value < 0.05 651 (5.7%) 681 (6.0%) 589 (5.8%)
Genes in PPI and FDR < 0.6 56 (0.49%) 6 (0.05%) 46 (0.45%)
No. of modules Initial dmGWAS modules 10,910 10,786 9,481
① evaluation, P(Z m) < 0.05 786 123 612
② evaluation in Affy6, P(Z m(eval)) < 0.05 17 - 41
③ evaluation in Affy500K, P(Z m(eval)) < 0.05 11 19 -
④ evaluation in MGS, P(Z m(eval)) < 0.05 - 34 5
Final modules: ①∩(②∪③∪④) 27 6 46
Involved genes (238) 68 29 146
Genes with P-value < 0.05 34 (50%) 17 (58.6%) 83 (56.8%)
Genes with FDR < 0.6 9 (13.24%) 6 (20.69%) 15 (10.27%)