Table 2. Results for gene-based test and dynamic module search of three schizophrenia GWAS datasets.
GWAS datasets | MGS | Affy6 | Affy500K | |
---|---|---|---|---|
No. of genes | Total genes | 27,188 | 26,899 | 23,420 |
Genes in PPI | 11,456 | 11,362 | 10,232 | |
Genes in PPI and P-value < 0.05 | 651 (5.7%) | 681 (6.0%) | 589 (5.8%) | |
Genes in PPI and FDR < 0.6 | 56 (0.49%) | 6 (0.05%) | 46 (0.45%) | |
No. of modules | Initial dmGWAS modules | 10,910 | 10,786 | 9,481 |
① evaluation, P(Z m) < 0.05 | 786 | 123 | 612 | |
② evaluation in Affy6, P(Z m(eval)) < 0.05 | 17 | - | 41 | |
③ evaluation in Affy500K, P(Z m(eval)) < 0.05 | 11 | 19 | - | |
④ evaluation in MGS, P(Z m(eval)) < 0.05 | - | 34 | 5 | |
Final modules: ①∩(②∪③∪④) | 27 | 6 | 46 | |
Involved genes (238) | 68 | 29 | 146 | |
Genes with P-value < 0.05 | 34 (50%) | 17 (58.6%) | 83 (56.8%) | |
Genes with FDR < 0.6 | 9 (13.24%) | 6 (20.69%) | 15 (10.27%) |