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. 2015 Jul 20;10(7):e0132774. doi: 10.1371/journal.pone.0132774

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Fig 1 — (A) The state of the system (red sphere) at rest in the typical homeostatic stable state. (B) Small external perturbation (green arrow) moves the system out of homeostasis, but dynamics return the system to its typical resting state (red arrow). (C) Large external perturbation moves the system into the basin of an alternate homeostatic stable state, but is held at a distance due to a continuing insult (green wedge). (D) Treatment course designed to move system back into the typical healthy basin of attraction. This image is a reproduction of the original found in [15] and presented under the Systems Biomedicine Creative Commons Attribution-NonCommercial 3.0 Unported License.