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. 2015 Jul 13;10:4479–4490. doi: 10.2147/IJN.S84930

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Confocal luminescence microscopy showing the in vivo distribution and amount of RFP expressed after transfection by naked plasmid or nanoparticles. Upper panel shows Gd-DTPA/pRFP (Gd-DTPA), middle panel shows Gd-DP/pRFP (Gd-DP), and lower panel shows Gd-DPT/pRFP (Gd-DPT). Red indicates RFP, blue indicates DAPI-stained cell nuclei, and yellow lines indicate crevices in tumor tissue. Original magnification 200×.

Abbreviations: Gd, gadolinium; DAPI, 4,6-diamidino-2-phenylindole; pRFP, plasmid red fluorescence protein; DGL, dendrigraft poly-L-lysine; PEG, polyethylene glycol; DTPA, gadopentetate dimeglumine; DP, DTPA-DGL-PEG; DPT, DTPA-DGL-PEG-TAT.