Table 3. Multivariable linear regression for the associations between FGF23 concentrations and the best subset of FGF23 correlates, mutually adjusted for each other.
Whole study population | Exclusion eGFR < 60 mL/min/1.73m2 | |||
---|---|---|---|---|
Parameter | β coefficient (95% CI) | P value a | β coefficient (95% CI) | P value a |
n = 2134 | n = 2061 | |||
Men | -0.21 (-0.28;-0.14) | <0.001 | -0.22 (-0.30;-0.15) | <0.001 |
Physical activity, Q2 | -0.0004 (-0.07;0.07) | 0.99 | -0.003 (-0.07;0.07) | 0.93 |
Physical activity, Q3 | -0.01 (-0.08;0.07) | 0.89 | -0.01 (-0.08;0.07) | 0.89 |
Physical activity, Q4 | 0.07 (-0.01;0.15) | 0.08 | 0.08 (-0.01;0.16) | 0.07 |
Smokers | 0.12 (0.06;0.18) | <0.001 | 0.12 (0.06;0.19) | <0.001 |
PTH, pg/mL b | 0.13 (0.08;0.17) | <0.001 | 0.13 (0.08;0.16) | <0.001 |
Creatinine, mg/dL b | 0.28 (0.14;0.41) | <0.001 | 0.27 (0.11;0.43) | 0.001 |
Total cholesterol, mg/dL | 0.001 (0.00003;0.001) | 0.04 | 0.001 (0.0001;0.001) | 0.01 |
HDL-cholesterol, mg/dL | -0.002 (-0.003;-0.0001) | 0.06 | -0.002 (-0.003;-0.0001) | 0.04 |
C-reactive protein, mg/dL b | 0.03 (0.01;0.05) | 0.01 | 0.02 (-0.001;0.04) | 0.07 |
Total protein intake, Q2 | 0.04 (-0.04;0.11) | 0.37 | 0.02 (-0.06;0.10) | 0.63 |
Total protein intake, Q3 | -0.03 (-0.11;0.06) | 0.41 | -0.05 (-0.13;0.03) | 0.21 |
Total protein intake, Q4 | -0.04 (-0.12;0.05) | 0.42 | -0.05 (-0.15;0.04) | 0.23 |
Calcium intake, mg/dL b | 0.10 (0.03;0.18) | 0.01 | 0.04 (-0.07;0.15) | 0.45 |
Iron intake, mg/d b | -0.25 (-0.42;-0.08) | 0.005 | -0.29 (-0.47;-0.12) | 0.001 |
Alcohol intake, g/d b | -0.02 (-0.04;-0.002) | 0.03 | -0.02 (-0.04;-0.001) | 0.07 |
Energy intake, kcal/d b | 0.25 (0.08;0.42) | 0.003 | 0.21 (0.01;0.40) | 0.03 |
eGFR stands for estimated glomerular filtration rate; Q2, Q3, Q4 stand for quartile 2, 3 and 4.
a Based on mutual adjustment.
b Natural log transformed.