Table 1.
drug | effect on TRPV1 | condition | phase |
---|---|---|---|
capsaicin | agonist | dysphagia, aspiration, swallow response, videofluoroscopy, sensorial neurostimulation | phase 2 |
resiniferatoxin | agonist | pain/cancer | phase 1 |
intrathecal resiniferatoxin | agonist | pain, intractable | phase 2 |
civamide nasal spray | agonist | dry eye | phase 2 |
civamide nasal solution | agonist | episodic cluster headache | phase 3 |
30% mannitol in vehicle cream | antagonist | pain | efficacy study |
JNJ-39439335 | antagonist | pain | phase 1 |
SYL1001 | antagonist | ocular pain | phase 1 |
AZD1386 | antagonist | pain | phase 2 |
DWP05195 | antagonist | postherpetic neuralgia | phase 2 |
SB-705498 | antagonist | migraine, acute | phase 2 |
SB-705498 | antagonist | toothache | phase 2 |
SB-705498 | antagonist | nonallergic rhinitis | phase 2 |
SB-705498 | antagonist | dermatitis, atopic | phase 1 |
SB-705498 | antagonist | irritable colon, fecal urgency, irritable bowel syndrome | phase 2 |
XEN-D0501 | antagonist | chronic obstructive pulmonary disease | phase 2 |
XEN-D0501 | antagonist | chronic idiopathic cough | phase 2 |
These data are from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.