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Estimated function per HSC from primary and secondary recipients
| Genotype | Input CD34− LKS (×103) |
Output BMNCs (×106) |
BMNCs per CD34− LKS (×103) |
Output CD34− LKS (×103) |
Fold increase of CD34− LKS |
|---|---|---|---|---|---|
| p18−/− | 2.62 | 118 ± 17.2 | 45.1 ± 6.58* | 609 ± 113 | 233* |
| p27−/− | 0.74 | 15.2 ± 1.08 | 20.4 ± 1.46 | 5.09 ± 0.79 | 6.9 |
| WT | 0.51 | 8.23 ± 0.77 | 16.1 ± 1.50 | 1.29 ± 0.41 | 2.5 |
BMNC, bone marrow nucleated cell; HSC, haematopoietic stem cell; WT, wild type.
