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. 2014 Feb 27;18(6):1004–1017. doi: 10.1111/jcmm.12246

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© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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BMI1 indirectly inhibits Runx1 and Pten expression with histone deacetylation. (A) The heat map of poor diagnosis genes in six MDS CD34+ cells of two refractory anaemia (RA), two RA with excess blasts I (RAEB-1) and two RAEB-2 compared to the normal control on the cDNA microarray. (B) The relative transcription of Runx1 and Pten tested by Q-PCR in K562. The transcript level in K562 was set to 1. (C and D) The histone H3 acetylation (H3ac) and histone H4 acetylation (H4ac) at Runx1 and Pten promoter regions tested by chromatin immunoprecipitation (ChIP) and Q-PCR assay in K562, n = 3. The histone modification in 10% input DNA was set to 1. IgG was as negative control.