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. 2014 Mar 18;18(6):1157–1171. doi: 10.1111/jcmm.12261

Figure 3.

Figure 3

XBP1S stimulates chondrogenesis in vitro. (A) Comparisons of XBP1S and BMP2 in stimulations of chondrogenesis of ATDC5 cells and murine bone marrow stromal cells (BMSCs; B). Micromass cultures of ATDC5 and BMSC cells were incubated in the absence (CTR) or presence of either 300 ng/ml BMP2, Ad-XBP1S (MOI 20) and Ad-XBP1S (MOI 20)+BMP2 for 3 or 7 days, and the mRNA levels of Col II (A and D), Col X (B and E), RUNX2 (C and F) were determined using real-time PCR. The units are arbitrary, and the normalized values were calibrated against control (CTR), here given the value of 1. The asterisk (*) indicates significant increase or decrease from control (*P < 0.05).