Figure 6.

Targeting expanded repeating RNAs that cause or contribute to microsatellite disorders. A) Two-dimensional representation of a hairpin with multiple internal loops formed by expanded microsatellite repeats with examples of repetitive nucleotide sequences. B) Three-dimensional structure of r(CGG)₃ fragment, PDB ID 3SJ2 (Kumar et al., 2011b). Coloring scheme is the same as for Figure 2. C) Targeting repetitive structural elements with small molecules, modularly assembled multivalent binders with increased affinity and selectivity, and in cellulo oligomerization as an ultimate strategy for precise targeting of expanded RNA repeats.