Table 1.
Statistics for target coverage and functional bone marrow (SUV4 region in FLT-1 PET) sparing in IMPT in static and error scenarios. For target coverage, dose to 99% of CTV was compared to 95% of prescription dose (Rx) 42.8 Gy in one-sample Wilcoxon signed-rank test; target coverage was maintained if D99% ≥ 95%Rx. For sparing of bone marrow (represented by SUV4 in FLT-PET), dose volume was compared to IMRT plans using paired Wilcoxon signed-rank tests.
| IMRT | IMPT Static |
IMPT Worst |
IMPT Average +3% |
IMPT Average −3% |
IMPT Average 0% |
||
|---|---|---|---|---|---|---|---|
| CTV Cervix D99% (Gy) |
Median (Min-Max) |
45.7 (45.2–46.6) |
45.0 (44.5–45.3) |
41.1 (37.5–44.9) |
44.6 (42.0–45.1) |
45.4 (44.8–46.1) |
45.5 (45.0–45.9) |
| p-value | <.01 | <.01 | 0.16 | 0.01 | <.01 | <.01 | |
| CTV Cervix DMean (Gy) |
Median (Min-Max) |
48.2 (47.3–49) |
47.2 (46.9–48.3) |
46.8 (45.9–47.0) |
47.0 (46.6–47.6) |
47.4 (47.0–49.1) |
47.2 (47.0–48.3) |
| p-value | <.01 | <.01 | <.01 | <.01 | <.01 | <.01 | |
| CTV Nodes D99% (Gy) |
Median (Min-Max) |
45.7 (45.0–46.9) |
44.8 (43.4–45.7) |
41.6 (37.3–44.6) |
43.9 (42.8–46.3) |
45.0 (44.3–45.5) |
45.5 (43.9–46.0) |
| p-value | <.01 | <.01 | 0.28 | <.01 | <.01 | <.01 | |
| CTV Nodes DMean (Gy) |
Median (Min-Max) |
48.4 (47.1–48.6) |
47.3 (46.9–48.1) |
46.9 (46.3–47.4) |
47.2 (46.6–47.8) |
47.7 (47.1–48.6) |
47.4 (47.0–48.2) |
| p-value | <.01 | <.01 | <.01 | <.01 | <.01 | <.01 | |
| SUV4 V5Gy (%) |
Median (Min-Max) |
78.8 (64.6–83.6) |
50.8 (47.3–76.5) |
56.7 (54.7–78.0) |
52.2 (48.1–76.9) |
56.1 (54.3–77.7) |
53.8 (50.5–77.3) |
| p-value | Reference | <.01 | <.01 | <.01 | <.01 | <.01 | |
| SUV4 V10Gy (%) |
Median (Min-Max) |
72.5 (58.4–77.8) |
39.5 (30.5–61.1) |
45.9 (34.7–63.8) |
39.3 (30.4–61.2) |
45.5 (34.0–63.6) |
42.5 (31.8–62.1) |
| p-value | Reference | <.01 | <.01 | <.01 | <.01 | <.01 | |
| SUV4 V15Gy (%) |
Median (Min-Max) |
70.3 (54.5–74.0) |
32.2 (25.8–54.5) |
39.6 (29.1–57.7) |
31.2 (23.8–54.0) |
38.2 (28.6–57.3) |
34.1 (26.6–55.4) |
| p-value | Reference | <.01 | <.01 | <.01 | <.01 | <.01 | |
| SUV4 V20Gy (%) |
Median (Min-Max) |
60.7 (50.4–69.5) |
27.4 (20.6–48.0) |
34.5 (25.8–52.8) |
25.8 (17.8–46.8) |
32.1 (25.2–51.7) |
28.4 (22.5–49.2) |
| p-value | Reference | <.01 | <.01 | <.01 | <.01 | <.01 | |
| SUV4 V35Gy (%) |
Median (Min-Max) |
46.0 (33.3–55.1) |
15.9 (9.3–27.7) |
23.5 (17.9–34.1) |
13.9 (5.8–24.5) |
18.8 (13.8–31.0) |
15.5 (9.0–27.6) |
| p-value | Reference | <.01 | <.01 | <.01 | <.01 | <.01 | |
| SUV4 V40Gy (%) |
Median (Min-Max) |
37.5 (22.6–44.6) |
12.3 (6.0–20.3) |
19.7 (13.6–26.1) |
8.3 (2.9–16.4) |
14.6 (9.5–22.2) |
11.4 (5.5–19.3) |
| p-value | Reference | <.01 | <.01 | <.01 | <.01 | <.01 |