Figure 1. Evaluation of human Schlemm's canal cell growth on well defined, microfabricated, porous SU-8 scaffolds.
(a) Scanning electron microscopy (SEM) images showing that HSC cell growth on SU-8 scaffolds depended on the coating for biochemical signals and was independent of the pore size. Scale bar = 100 μm. (b) Schematic of the polymerization scheme for Extracel (HA-GelinS). (c) SEM images of SU-8 scaffolds (12-μm pores) coated with 1 % gelatin or Extracel (ESU-8) (top panel). SEM images revealing establishment of a continuous HSC monolayer on the Extracel-coated SU-8 scaffold (bottom panel). Scale bar = 100 μm. (d) Live cell count demonstrating over 2-fold increase in HSC cell growth on ESU-8 scaffolds compared to gelatin-coated scaffolds. * (P< 0.001, Extracel vs 1 % gelatin) Mean ± SD with N= 4.