Table I.
Average Acceleration Values (g, RMS) Measured Over the Release Experiments with USP Prednisone Tablets RS 10 mg Tablets at Paddle Speeds of 50, 75, and 100 rpm and Different Vibration Levels
| Acceleration (g, RMS) | ||||
|---|---|---|---|---|
| Agitation rate | Vibration level | z | y | x |
| 50 rpm | No vibration | 0.0097 ± 0.0021 | 0.0018 ± 0.0008 | 0.0014 ± 0.0005 |
| 50 rpm | Level 1 | 0.0107 ± 0.0034 | 0.0044 ± 0.0007 | 0.0034 ± 0.0005 |
| 50 rpm | Level 2 | 0.0101 ± 0.0013 | 0.0068 ± 0.0005 | 0.0045 ± 0.0002 |
| 50 rpm | Level 3 | 0.0331 ± 0.0040 | 0.0609 ± 0.0023 | 0.0272 ± 0.0009 |
| 75 rpm | No vibration | 0.0105 ± 0.0023 | 0.0061 ± 0.0004 | 0.0036 ± 0.0003 |
| 75 rpm | Level 1 | 0.0173 ± 0.0012 | 0.0050 ± 0.0004 | 0.0039 ± 0.0003 |
| 75 rpm | Level 2 | 0.0130 ± 0.0015 | 0.0035 ± 0.0006 | 0.0034 ± 0.0003 |
| 75 rpm | Level 3 | 0.0686 ± 0.0018 | 0.0271 ± 0.0031 | 0.0290 ± 0.0005 |
| 100 rpm | No vibration | 0.0064 ± 0.0007 | 0.0063 ± 0.0004 | 0.0040 ± 0.0002 |
| 100 rpm | Level 1 | 0.0076 ± 0.0025 | 0.0057 ± 0.0005 | 0.0049 ± 0.0003 |
| 100 rpm | Level 2 | 0.0073 ± 0.0006 | 0.0065 ± 0.0004 | 0.0034 ± 0.0003 |
| 100 rpm | Level 3 | 0.0772 ± 0.0032 | 0.0195 ± 0.0006 | 0.0290 ± 0.0008 |