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Variables Used in Placket Burman Experimental Design
| Independent variables (factors) | Levels | ||
|---|---|---|---|
| −1 | +1 | ||
| Numeric factors | Concentration of β-cyclodextrin (A) | 0.5 mg/ml | 4 mg/ml |
| pH of β-cyclodextrin (B) | 3 | 8 | |
| Concentration of alginate (C) | 0.1 mg/ml | 1 mg/ml | |
| concentration of TMC (D) | 0.5 mg/ml | 2 mg/ml | |
| pH of TMC solution (E) | 3 | 6 | |
| Concentration of CaCl2 (F) | 5 mg/ml | 30 mg/ml | |
| Dependent variables (responses) | Constrains | ||
| Y 1 = size (nm) | Minimize | ||
| Y 2 = PdI | Minimize | ||
| Y 3 = Entrapment efficiency (EE%) | Maximize | ||
