Table II.
Plackett Burman Experimental Design Runs (n = 3)
| No | Independent variables | Dependent variables | |||||||
|---|---|---|---|---|---|---|---|---|---|
| βCD conc. (A) (mg/ml) | βCD pH (B) | Alginate conc. (C) (mg/ml) | TMC conc. (D) (mg/ml) | TMC pH (E) | CaCl2 conc. (F) (mg/ml) | Size (Y 1) (nm) | PdI (Y 2) | EE (Y 3) (%) | |
| 1 | 4 | 3 | 1 | 0.5 | 3 | 5 | 1505.6 ± 68.16 | 0.84 ± 0.14 | 96.63 ± 1.06 |
| 2 | 4 | 8 | 0.1 | 2 | 6 | 5 | 286 ± 65.5 | 0.29 ± 0.1 | 99.2 ± 0.26 |
| 3 | 4 | 8 | 1 | 0.5 | 6 | 30 | 2023 ± 419 | 0.97 ± 0.03 | 98.4 ± 0.17 |
| 4 | 4 | 3 | 0.1 | 0.5 | 6 | 30 | 552.3 ± 82.9 | 0.57 ± 0.06 | 96.9 ± 0.25 |
| 5 | 0.5 | 3 | 0.1 | 0.5 | 3 | 5 | 350.6 ± 164.5 | 0.54 ± 0.1 | 99.7 ± 0.06 |
| 6 | 0.5 | 3 | 1 | 2 | 6 | 5 | 1886.6 ± 940 | 0.73 ± 0.25 | 100.5 ± 0.0 |
| 7 | 0.5 | 8 | 0.1 | 0.5 | 3 | 30 | 974.3 ± 486 | 0.62 ± 0.09 | 99.6 ± 0.15 |
| 8 | 0.5 | 8 | 1 | 0.5 | 6 | 5 | 2393 ± 1219 | 0.85 ± 0.15 | 99.6 ± 0.43 |
| 9 | 0.5 | 3 | 0.1 | 2 | 6 | 30 | 1011.6 ± 635.2 | 0.76 ± 0.31 | 99.8 ± 0.11 |
| 10 | 0.5 | 8 | 1 | 2 | 3 | 30 | – | – | – |
| 11 | 4 | 3 | 1 | 2 | 3 | 30 | – | – | – |
| 12 | 4 | 8 | 0.1 | 2 | 3 | 5 | 187 ± 20.07 | 0.34 ± 0.01 | 99.8 ± 0.11 |
EE% entrapment efficiency