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PI3K pathway alterations in patients treated at the maximum tolerated dose who remained on-study for > 2 cycles
| Patient | PI3K amplification |
PI3K mutation |
PTEN status | Response |
|---|---|---|---|---|
| 1^ | No | Not evaluable | Absent | SD |
| 2 | No | Yes | Absent | SD |
| 3 | No | No | Present | SD |
| 4 | Not evaluable | No | Absent | SD |
| 5 | No | No | Present | SD |
| 6 | No | No | Absent | SD |
| 7 | Not evaluable | Not evaluable | Absent | SD |
| 8 | No | No | Present | SD |
| 9* | No | No | Absent | SD |
Last dose: day 8 of cycle 3;
last dose: day 7 of cycle 3.
