Table 3.

The number of SNPs in COPDGene sample passing genome-wide significant level 5 × 10⁻⁷ by different methods and the minimum and maximum –log₁₀(p-value) when using FEV₁, FEV₁/FVC, and log(pctEmph).

Chr	Nearest Gene		MaxH		PCA		Multivariate		MultiPhen
			Min	Max	Min	Max	Min	Max	Min	Max
1	*TGFB2	Num –log10(P)					2
							6.5	6.7
4	#FAM13A	Num –log10(P)	2
			6.3	6.4
4	# HHIP	Num –log10(P)	6		7		5
			6.4	7.8	6.4	8.3	7.9	8.3
6	*AGER	Num –log10(P)			1		1		1
					7.6	7.6	6.8	6.8	6.8	6.8
11	*MMP12	Num –log10(P)	1		1
			6.4	6.4	6.3	6.3
15	# CHRNA3-5 AGPHD1 IREB2	Num –log10(P)	13		15		13		9
			6.3	10.9	6.5	9.0	6.5	11.3	6.3	8.3
18	PTPRM	Num –log10(P)					1
							6.6	6.6

^#confirmed in prior COPD GWAS

^*supportive evidence from other studies

See text.