Table 1.
The main algorithms for computational miRNA-target prediction
| Algorithm | Features | Approach | References |
|---|---|---|---|
| HHMMiR | Seed match, and conservation | HMM | 51 |
| PicTar | Seed match | HMM | 52 |
| MiRFinder | Seed match, and conservation | SVM | 53 |
| RNAmicro | Sequence composition, conservation, and thermodynamic stability | SVM | 54 |
| ProMir | Sequence composition, conservation and thermodynamic stability. | HMM | 55 |
| MiRRim | Sequence composition, conservation, and free energy. | HMM | 56 |
| BayesMiRNAFind | Sequence composition and free energy. | Naïve Bayes Classifier | 57 |
| SSCprofiler | Sequence composition, conservation and free energy. | HMM | 58 |
| Diana-microT | Seed match, conservation, and free energy | Dynamic programming algorithm | 59 |
| TargetScan | Seed match, conservation, and free energy | Combinatorial score | 40 |
| MiRanda | Seed match, conservation, and free energy | Score | 60 |