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. 2015 Jul 21;5:10809. doi: 10.1038/srep10809

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(A) Schema of IdeS treatment for complement deposition. Complement C3 deposition mediated by anti-ganglioside IgG antibodies was detected on the microtiter plates. IdeS treatment cleaved IgG autoantibodies and prevented subsequent complement activation. (B) Blocking effect of IdeS on complement deposition. IdeS blocked C3 deposition mediated by IgG autoantibodies against GM1, GD1a and GQ1b, respectively. (C) Concentration dependence of IdeS treatment. The representative change of C3 deposition mediated by GM1-IgG depends on its concentration. The blocking effect of C3 accumulated to the highest levels at a concentration of 10 μg/ml or more of IdeS.