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Influenza vaccines.
| Characteristics | Current FDA-approved vaccines |
New vaccines |
||
|---|---|---|---|---|
| IIV | LAIV | RIV | CPB/CB | |
| Safety | ++ | + | ++ | ++ |
|
| ||||
| Immunogenicity | + | ++ | + | ++ |
|
| ||||
| Humoral response | Yes | Yes | Yes | Yes |
|
| ||||
| Cellular response | Weak | Yes | Weak | Yes |
|
| ||||
| Manufacturing method |
Egg-based production | Tissue culture (insect) | Tissue culture (mammalian) | |
CB: Codon bias; CPB: Codon pair bias; IIV: Inactivated influenza vaccine; LAIV: Live attenuated influenza vaccine; RIV: Recombinant influenza vaccine.
