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Codon deoptimized viruses used as vaccines.
| Virus | Approach | Genes modified |
In vivo
attenuation |
Protection and immunogenicity |
Ref. |
|---|---|---|---|---|---|
| Respiratory syncytial virus |
CPB CB |
NS1, NS2, N, P, M, SH, G, F, L NS1 and NS2 |
Yes Yes |
Yes Yes |
[65] [63] |
|
| |||||
| Poliovirus | CPB | P1 capsid region |
Yes | ND | [52] |
|
| |||||
| Influenza virus | CPB CB |
PB1, HA, NP, NA NS |
Yes Yes |
Yes Yes |
[57,64] [55] |
CB: Codon bias; CPB: Codon pair bias; ND: Not determined.
