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. 2015 Jul 20;210(2):303–318. doi: 10.1083/jcb.201411001

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© 2015 Gomez-Lamarca et al.

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Figure 5. — Combined depletion of Rme-8 with Vps-26 results in ectopic Notch activation. (A–B′) NRE-mCherry is ectopically expressed in Vps26-Ri;Rme8-Ri (B) compared with Vps26-Ri;w-Ri (A). (C–D′) Wg accumulates inside both producing and receiving cells in Vps26-Ri;Rme8-Ri (D) but only in producing cells in Vps26-Ri;w-Ri (C). (E–H″) NICD and Rab7 distribution in Vps26-Ri;w-Ri (E and F) or Vps26-Ri;Rme-8-Ri (G and H) wing discs. Apical (E and G) and subapical focal planes (F and H) with xz cross sections from discs in F and H beneath. (I and J) TEM images of Vps26-Ri;Rme8-Ri (I) with endosomes colored in yellow, and quantification of endosomal perimeter from TEM images (J; WT n = 83; Vps26-Ri+Rme-8-Ri n = 30). Boxes indicate 25th to 75th percentiles, whiskers represent maximum and minimum values in the dataset, and lines show the median values.