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. 2015 Jul 21;5:12376. doi: 10.1038/srep12376

Table 2. Genes in ancestry-enriched regions and their associated traits.

Gene Function Ancestry Associated trait Evidence PMID Ancestry enrichment (-log10P)
ADCY3 Adenylate cyclase 3 Asian Body mass index Positive Selection 22344219 18.6
ATM Ataxia telangiectasia mutated Asian Cell cycle Association Study 24390342, 21983787 15.7
BCHE Butyrylcholinesterase African Cardiovascular disease risk in European Association Study 23419831, 21943158, 9780523 23.7
CASP8 Caspase 8, apoptosis-related cysteine peptidase Asian Reduces breast cancer risk Positive Selection 17293864 9.6
CD226 CD226 molecule Asian Adaptive immune system, cell adhesion Positive Selection 24390342, 23128233, 21829393, 17554260 34.5
HLA-B Major histocompatibility complex, (MHC) class I, B African Immune response Positive Selection 23731540, 16998491 31.6
MANBA Mannosidase Asian Decreases colorectal cancer risk & associated with mannosidosis Association Study 17899454, 21833088 29.7
MAPK10 Mitogen-activated protein kinase 10 Asian Immune system Association Study 25634076 25.4
MICA MHC class I polypeptide-related sequence A African Immune response Positive Selection 23731540 32.6
NANOS3 Nanos homolog 3 Asian Germ cell development Association Study 21421998 23.9
NFKB1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Asian Reduces breast cancer risk Positive Selection 22562547 30.8
SF3B4 Splicing Factor 3b, Subunit 4 Asian Height Association Study 20881960, 18391951 30.6
SLC24A5 Solute carrier family 24, member 5 European Decreases melanin pigmentation in skin Positive Selection 17182896 16.1
SLC44A2 Solute carrier family 44, member 2 European Metabolism Association Study 22040064 20.1
ULBP1 UL16 binding protein 1 European Cytosolic DNA sensing pathway Association Study 20923822 12.3
USP32 Ubiquitin Specific Protease 32 Asian Overexpressed in breast cancer Positive Selection 19307593 36.4