Table 10.

GABA transporter GAT1.

Function/dysfunction	Findings	References
GAT1 KO mice and ADHD	Hyperactive behavior and memory dysfunctions in the MWM, also have low levels of attention and increased impulsivity	Yang et al., 2013
GABA-transporter inhibitor	Tiagabine, in the MWM, compared to saline treated rats, impaired learning during the acquisition trials. And retrieval only at the probe trial	Schmitt and Hiemke, 2002
GAT1(−/−) KO mice	Impaired hippocampus-dependent learning and memory (MWM, PA)	Shi et al., 2012
GABAergic immunotoxin: GAT1-saporin (GAT1-SAP)	Intraseptal impaired a delayed match to position task and extinction of avoidance without altering acquisition of WMWM, active avoidance acquisition or open field behavior. Also, animals were slower to update changes to previous contingencies	Pang et al., 2011; but see Köppen et al., 2013
GAT1(+/−) mice	Increased learning and memory, decreased anxiety-like behaviors, and highest synaptic plasticity compared with wild-type and homozygous GAT1(−/−) mice	Shi et al., 2012

ADHD, attention deficit and hyperactivity disorder; KO, knock out; MWM, Morris water maze; PA, passive avoidance.