Table 11.

Glutamate transporter 1 and markers.

Function/dysfunction	Findings	References
Glutamate and AD	Reduced mRNA levels of VGLUTs, EAAT1-3 proteins	Chen et al., 2011
MDMA	Improved expression of GluR2 receptor, mGluR1, mGluR5, NR1, NR2A, NR2B and EAAT1, EAAT2-2 transporters. Increased mRNA levels of GluR3, NR2A and NR2B in caudate putamen. GluRl is reduced in the hippocampus, in hypothalamus increases expression of GluRl, GluR3, and mGluR3 mGluR	Kindlundh-Högberg et al., 2008, 2010
Mild stress model induced	Mice heterozygous (+/− VGLUT1) VGLUT1 decrease expression relative to wild mice: dysfunctions in recognition memory (recognition new object); anhedonia (sucrose intake), hopelessness (forced swimming), anxiety (elevated plus maze)	Garcia-Garcia et al., 2009
Glutamate transporter 1 and training	The hippocampal levels of GLT-1 complex are parallel to training in the memory multiple T-maze test	Heo et al., 2012

AD, Alzheimer's disease; VGLUTs, Vesicular glutamate transporters; MDMA, methylenedioxymethamphetamine.