Table 5.
5HT3 receptor antagonist, neuroprotection.
| Function/dysfunction | Findings | References |
|---|---|---|
| AD | Tropisetron, a potent α7 nAChR agonist and 5-HT3 receptor antagonist, also bound to the ectodomain of amyloid precursor protein. Furthermore, tropisetron promoted greater improvements in memory current AD therapeutic drugs AD. | Hashimoto, 2015 |
| In addition, tropisetron represents an attractive potential therapeutic drug to delay or prevent MCI and AD. This drug is also used for the treatment of chemotherapy-induced emesis | Fakhfouri et al., 2014 | |
| Aβ rat model of AD in MWM | - Tropisetron might have a neuroprotective effect; tropisetron attenuated Aβ-induced hippocampal neuroinflammation | Hashimoto, 2015 |
| Subtypes of 5-HT3 receptor | Thompson, 2013 | |
| KO 5-HT3A receptor | Loss of exercise-induced hippocampal neurogenesis and antidepressant effects, but not of learning enhancement | Kondo et al., 2014 |
AD, Alzheimer's disease; MCI, middle cognitive impairment; MWM, Morris water maze.