Table 6.
5HT4 receptor.
| Function/dysfunction | Findings | References |
|---|---|---|
| Memory | Activation has promnesic effects in rodents and humans | Haahr et al., 2013; Peñas-Cazorla and Vilaró, 2014 |
| Mechanisms in cognition | Increased dendritic spines in the CA1 region of the hippocampus. Neuronal activity and increased release of acetylcholine in the prefrontal cortex and hippocampus. It is not synthesized in cholinergic cells Pre-training SL65.0155 enhances olfactory memory discrimination, inducing hippocampal growth dendritic spines; suggesting that selective 5-HT4 stimulation increases structural plasticity in learning activated hippocampal circuits | Restivo et al., 2008; Marchetti et al., 2011; Peñas-Cazorla and Vilaró, 2014 |
| Changes with age | Old rats decreased 5-HT4 expression and poor memory relative to adult | Waeber et al., 1996; Manuel-Apolinar et al., 2005; Marchetti et al., 2011 |
| Memory | Hippocampal 5-HT4 expression correlates inversely with memory in humans. | Haahr et al., 2013 |
| AD | This receptor and β-amyloid protein are present in early stages of AD | Madsen et al., 2011 |
AD, Alzheimer's disease.