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. 2015 Jun 9;10(2):835–840. doi: 10.3892/ol.2015.3344

Figure 2.

Figure 2.

CXCR4 is a target of miRNA150. (A) Predicted duplex formation between human CXCR4 3′-UTR and miRNA-150. (B) Luciferase report vector: The miRNA-150 binding site in the 3′-UTR and mutated sites in the 3′-UTR of CXCR4 were cloned into a luciferase report vector. (CXCR4-3′-UTR-pIS0/mu-CXCR4-3′-UTR-pIS0). (C) Luciferase activity of CaPan2 cells cotransfected with CXCR4-3′-UTR-pIS0 or mu-CXCR4-3′-UTR-pIS0, and miR-150 mimics or NC. *P<0.05 compared with CaPan2 cells cotransfected with CXCR4-3′UTR-pIS0 miRNA-150 mimics. CXCR4, C-X-C chemokine receptor type 4; UTR, untranslated region; miRNA, microRNA; NC, normal control; WT, wild type.