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Cisplatin and metformin co-treatment significantly decreases tumor growth and angiogenesis. Immunolocalisation of (A–D) Ki-67 and (E–H) cluster of differentiation 34 in xenograft tumors derived from BIU-87 bladder carcinoma cells. (A and E) Control group; and groups treated with (B and F) cisplatin, (C and G) metformin, and (D and H) metformin and cisplatin (magnification, x400).
