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IC50 values of DAC in HCT116 cells following long-term treatment with DAC.
| DAC treatment | IC50 (µM) | Relative resistance |
|---|---|---|
| Control | 8.6±2.7 | 1.0 |
| Day 28 | 4.3±1.7 | 0.5 |
| Day 52 | 12.2±3.8 | 1.4 |
| Day 81 | 872.4±152.0 | 101.4 |
| Day 104 | 884.2±85.9 | 102.8 |
Values are presented as the mean ± standard error of the mean of three independent experiments. Relative resistance = IC50(DAC-treated cells)/IC50(control cells). DAC, decitabine.
