Table II.
IC50 values of epigenetic modifiers in control and DAC-resistant HCT116 cells.
| Epigenetic modifiers | AC (µM) | Zeb (µM) | TSA (nM) | SAHA (µM) | VPA (mM) |
|---|---|---|---|---|---|
| Control | 18.28±0.56 | 1040.15±73.21 | 23.99±4.92 | 0.64±0.05 | 1.22±0.02 |
| DAC-resistant | 16.36±0.88 | 918.11±85.72 | 17.15±1.70 | 0.48±0.04 | 0.94±0.04 |
| Relative resistance | 0.89 | 0.88 | 0.71 | 0.75 | 0.77 |
| P-value | 0.14 | 0.34 | 0.26 | 0.05 | 2.30×10−3a |
Values are presented as the mean ± standard error of the mean of three independent experiments. Resistance = IC50(DAC-treated cells)/IC50(control cells).
a
P<0.05 indicates statistical significance. DAC, decitabine; AC, azacitidine; Zeb, zebularine; TSA, trichostatin A; SAHA, vorinostat; VPA, valproic acid.