Table II.
Initial treatment of patients with extensive-stage small-cell lung cancer in the ChT/TRT and ChT groups.
| Treatment | ChT/TRT group (n) | ChT group (n) |
|---|---|---|
| No. of ChT cycles prior to TRT | ||
| 1 | 4 | - |
| 2 | 32 | - |
| 3 | 15 | - |
| 4 | 13 | - |
| 5 | 5 | - |
| 6 | 13 | - |
| No. of initial ChT cycles | - | |
| 3 | 1 | 2 |
| 4 | 16 | 21 |
| 5 | 11 | 7 |
| 6 | 29 | 33 |
| 7 | 9 | 6 |
| 8 | 16 | 14 |
| ChT regimen | - | |
| EP | 67 | 62 |
| CE | 15 | 21 |
| Response to ChT prior to TRT | - | |
| CR | 2 | - |
| PR | 68 | - |
| SD | 11 | - |
| PD | 1 | - |
| TRT dose (Gy) | - | |
| 40 | 5 | - |
| 42 | 1 | - |
| 44 | 4 | - |
| 45 | 22 | - |
| 46 | 1 | - |
| 48 | 4 | - |
| 50 | 12 | - |
| 52 | 3 | - |
| 54 | 3 | - |
| 56 | 5 | - |
| 58 | 1 | - |
| 60 | 20 | - |
| 62 | 1 | - |
| Radiation dosing | - | |
| 1.5 Gy/fraction BID | 22 | - |
| 2 Gy/fraction QD | 20 | - |
| PCI 30 Gy | 3 | 2 |
| WBRT | 38 | 26 |
| Bone RT | 31 | 33 |
ChT, chemotherapy; TRT, thoracic radiation therapy; Gy, grays; EP, combined cisplatin and etoposide; CE, combined carboplatin and etoposide; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; BID, twice daily; QD, daily; PCI, prophylactic cranial irradiation; RT, radiotherapy; WBRT, whole-brain radiotherapy.