(A–C) Immunohistochemical staining showing islet cells positive for (A) synaptophysin (magnification, x100) (B) chromogranin A (magnification, x100) and (C) neuron-specific enolase (magnification, x100). (D) Insulin staining showing enlarged, insulin-secreting β cells (magnification, x100). (E) Islets showing almost no Ki-67 staining (magnification, x200).