Table II.
Histopathological damage parameters detected in the rat pulmonary tissue samples.
| Histopathological parameter | Control | Silibinin | MTX | MTX + silibinin |
|---|---|---|---|---|
| Interstitial lymphocytic inflammation | 0.125 | 0.375 | 1.25a,b | 0.25c |
| Interstitial fibrosis | 0 | 0 | 0.875a,b | 0c |
| Type 2 pneumocyte infiltration | 0 | 0 | 0.5a,b | 0c |
| Intraalveolar/interstitial macrophage existence | 0 | 0.375 | 0.5 | 0.125 |
| Eosinophil existence | 0 | 0.5 | 0.875a | 0.125c |
| Granuloma existence | 0 | 0 | 0.25 | 0 |
Results are presented as the mean ± standard deviation.
a
P<0.05, vs. control group
b
P<0.05, vs. silibinin group
c
P<0.05, vs. MTX group. MTX, methotrexate.