Table 2.

Association between PNPLA3 rs748309 polymorphisms and HCC risk

Study group	Simple size (Case/Control)	Genetic models		I2 (%)	Ph	Effect-model	OR [95% CI]	P
Overall	1016/3026	Allele contrast	G vs. C	0	0.50	Fixed	2.02 [1.77, 2.30]	<0.00001
		Dominant model	GG + CG vs. CC	0	0.41	Fixed	2.03 [1.70, 2.41]	<0.00001
		Recessive model	GG vs. CG + CC	0	0.91	Fixed	3.56 [2.70, 4.69]	<0.00001
		Co-dominant model	GG vs. CC	0	0.70	Fixed	4.40 [3.28, 5.91]	<0.00001
			CG vs. CC	0	0.42	Fixed	1.62 [1.34, 1.59]	<0.00001
		Over-dominant model	GG + CC vs. CG	5	0.39	Fixed	0.84 [0.71, 1.00]	0.05
Hepatitis virus	640/2957	Allele contrast	G vs. C	0	0.63	Fixed	1.44 [1.23, 1.68]	<0.00001
		Dominant model	GG + CG vs. CC	0	0.85	Fixed	1.40 [1.14, 1.72]	0.001
		Recessive model	GG vs. CG + CC	0	0.66	Fixed	2.15 [1.52, 3.04]	<0.001
		Co-dominant model	GG vs. CC	0	0.67	Fixed	2.35 [1.63, 3.38]	<0.00001
			CG vs. CC	0	0.87	Fixed	1.24 [1.00, 1.54]	0.05
		Over-dominant model	GG + CC vs. CG	0	0.74	Fixed	0.93 [0.75, 1.14]	0.47
Alcohol	255/2825	Allele contrast	G vs. C	0	0.7	Fixed	3.94 [3.21, 4.82]	<0.00001
		Dominant model	GG + CG vs. CC	13	0.33	Fixed	4.90 [3.52, 6.81]	<0.00001
		Recessive model	GG vs. CG + CC	0	0.94	Fixed	7.99 [5.56, 11.48]	<0.00001
		Co-dominant model	GG vs. CC	0	0.45	Fixed	14.65 [9.47, 22.64]	<0.00001
			CG vs. CC	34	0.21	Fixed	3.23 [2.27, 4.60]	<0.00001
		Over-dominant model	GG + CC vs. CG	46	0.14	Fixed	0.74 [0.56, 0.98]	0.03
HCV	505/1007	Allele contrast	G vs. C	0	0.67	Fixed	1.53 [1.28, 1.83]	<0.00001
		Dominant model	GG + CG vs. CC	0	0.65	Fixed	1.49 [1.18, 1.88]	0.0007
		Recessive model	GG vs. CG + CC	0	0.88	Fixed	2.39 [1.63, 3.50]	<0.00001
		Co-dominant model	GG vs. CC	0	0.82	Fixed	2.65 [1.77, 3.97]	<0.00001
			CG vs. CC	0	0.58	Fixed	1.28 [1.00, 1.64]	0.05
		Over-dominant model	GG + CC vs. CG	0	0.51	Fixed	0.92 [0.73, 1.17]	0.50