Table 3.
Association between PNPLA3 rs748309 polymorphisms and development of HCC in patients with cirrhosis
| Study group | Simple size (Case/Control) | Genetic models | I2 (%) | Ph | Effect-model | OR [95% CI] | P | |
|---|---|---|---|---|---|---|---|---|
| Overall | 461/876 | Allele contrast | G vs. C | 0 | 0.43 | Fixed | 1.39 [1.17, 1.64] | 0.0001 |
| Dominant model | GG + CG vs. CC | 5 | 0.35 | Fixed | 1.30 [1.03, 1.65] | 0.03 | ||
| Recessive model | GG vs. CG + CC | 0 | 0.78 | Fixed | 1.91 [1.41, 2.58] | <0.0001 | ||
| Co-dominant model | GG vs. CC | 0 | 0.52 | Fixed | 2.00 [1.43, 2.79] | <0.0001 | ||
| CG vs. CC | 4 | 0.35 | Fixed | 1.14 [0.89, 1.48] | 0.30 | |||
| Over-dominant model | GG + CC vs. CG | 0 | 0.54 | Fixed | 1.12 [0.88,1.41] | 0.36 | ||
| Alcohol | 212/425 | Allele contrast | G vs. C | 0 | 0.61 | Fixed | 1.82 [1.43, 2.32] | <0.0001 |
| Dominant model | GG + CG vs. CC | 0 | 0.5 | Fixed | 1.87 [1.28, 2.73] | 0.001 | ||
| Recessive model | GG vs. CG + CC | 0 | 0.55 | Fixed | 2.65 [1.75, 4.02] | <0.00001 | ||
| Co-dominant model | GG vs. CC | 0 | 0.37 | Fixed | 3.28 [2.01, 5.35] | <0.00001 | ||
| CG vs. CC | 0 | 0.48 | Fixed | 1.45 [0.96, 2.17] | 0.08 | |||
| Over-dominant model | GG + CC vs. CG | 0 | 0.56 | Fixed | 1.13 [0.80, 1.58] | 0.49 | ||
| HCV | 226/398 | Allele contrast | G vs. C | 19 | 0.29 | Fixed | 1.10 [0.86, 1.42] | 0.44 |
| Dominant model | GG + CG vs. CC | 0 | 0.42 | Fixed | 1.09 [0.78, 1.53] | 0.62 | ||
| Recessive model | GG vs. CG + CC | 0 | 0.46 | Fixed | 1.22 [0.74, 1.99] | 0.43 | ||
| Co-dominant model | GG vs. CC | 9 | 0.33 | Fixed | 1.23 [0.73, 2.07] | 0.43 | ||
| CG vs. CC | 0 | 0.63 | Fixed | 1.05 [0.73, 1.52] | 0.78 | |||
| Over-dominant model | GG + CC vs. CG | 0 | 0.85 | Fixed | 1.01 [0.71, 1.43] | 0.97 | ||