Table 1.
The effects of β2GPI and reduced β2GPI on the biochemical parameters and renal function of STZ-induced diabetic mice at the end of the experimental period. Data are expressed as the mean ± S.E.M. (n = 8 for each group)
| Groups | NC | DM | DM + β2-GPI | DM + reduced β2GPI | ||
|---|---|---|---|---|---|---|
|
| ||||||
| 3 wk | 6 wk | 3 wk | 6 wk | |||
| Body weight (g) | 24.58±2.53 | 22.48±3.11 | 23.39±1.65 | 24.04±2.83 | 24.33±2.76 | 23.72±2.42 |
| Kidney weight (g) | 134.69±19.40 | 263.09±15.81* | 212.02±22.41* | 205.30±22.69*,# | 210.45±30.49* | 186.34±15.04# |
| Kidney/body weight ratio (mg/g) | 5.57±1.40 | 11.88±1.93* | 9.04±0.33* | 8.56±0.64*,# | 8.64±0.59*,# | 7.88±0.63# |
| Blood glucose (mmol/L) | 6.05±0.86 | 25.66±3.21* | 23.89±6.43* | 23.78±6.21* | 24.49±5.55* | 22.40±4.28* |
| Serum creatinine (μmmol/L) | 7.29±1.23 | 23.64±5.07* | 17.17±3.06*,# | 15.98±5.89*,# | 16.14±3.93*,# | 13.20±1.71*,# |
| Blood urea nitrogen (mmol/L) | 5.23±0.65 | 12.57±1.24* | 9.75±1.22* | 8.10±0.84*,# | 8.60±1.43*,# | 8.33±1.34*,# |
| Urine albumin (μg/24 h) | 27.26±8.74 | 230.99±40.01* | 161.41±31.03* | 132.88±28.61*,# | 140.58±25.72*,# | 116.88±18.52*,# |
C: normal control; DM: diabetic model control; β2GPI: 20 μg β2GPI; reduced β2GPI: 20 μg reduced β2GPI. NC and DM were treated with equal volumes of PBS. All the mice were administered via intravenous injection.
*
P<0.05 vs. NC group.
#
P<0.05 vs. DM group.