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p38 MAPK and ERK1/2 are involved in ManLAM-induced IL-37 production. A. IL-37 production induced by medium (CM), iH37Rv or ManLAM inA549 cells for 24 h were examined by western blotting. B. ELISA analysis of the effect of various signal proteins’ inhibitors on the production of IL-37 in A549 cells induced by ManLAM for 24 h. C. Western blot analysis for detection of ERK1/2, p38, and β-actin activation in A549 cells stimulated by ManLAM. Data are expressed as mean ± SD.
