Table 2.
Meta-analysis of ABCB1 polymorphism and AMD risk
| Variables | TT vs. CC (FM) | TT + CT vs. CC (FM) | TT vs. CT + CC (RM) | T vs. C (FM) | CT vs. CC (FM) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||||
| OR (95% CI) | P h | I 2 | OR (95% CI) | P h | I 2 | OR (95% CI) | P h | I 2 | OR (95% CI) | P h | I 2 | OR (95% CI) | P h | I 2 | |
| Ethnicity | |||||||||||||||
| Total | 1.29 (1.08, 1.54) | 0.109 | 40.5% | 1.04 (0.93, 1.17) | 0.997 | 0 | 1.47 (1.02, 2.13) | < 0.10 | 76.7% | 1.14 (1.04, 1.25) | 0.101 | 41.6% | 0.95 (0.82, 1.10) | 0.427 | 0.2% |
| Caucasian | 1.07 (0.86, 1.34) | 0.778 | 0 | 1.02 (0.88, 1.17) | 0.979 | 0 | 1.07 (0.86, 1.32) | 0.375 | 5.5% | 1.03 (0.92, 1.15) | 0.757 | 0 | 1.00 (0.84, 1.19) | 0.954 | 0 |
| Asian | 1.79 (1.32, 2.43) | 0.183 | 41.1% | 1.09 (0.89, 1.34) | 0.964 | 0 | 2.55 (1.47, 4.43) | 0.044 | 68.0% | 1.38 (1.18, 1.62) | 0.503 | 0 | 0.84 (0.64, 1.11) | 0.067 | 63.0% |
| Source of control | |||||||||||||||
| Population | 1.17 (0.97, 1.42) | 0.546 | 0 | 1.04 (0.92, 1.18) | 0.991 | 0 | 1.26 (0.96, 1.65) | 0.052 | 52.0% | 1.09 (0.99, 1.20) | 0.441 | 0 | 1.01 (0.87, 1.18) | 0.994 | 0 |
| Hospital | 2.54 (1.46, 4.42) | - | - | 1.06 (0.75, 1.50) | - | - | 4.11 (2.41, 6.98) | - | - | 1.57 (1.20, 2.07) | - | - | 0.50 (0.30, 0.85) | - | - |
P h: P value of heterogeneity test; CI: confidence interval; OR: odds ratio; FM: fixed-effects model; RM: random-effects model.