Table 4.
Cox regression analysis of risk factors associated with disease free survival of HCC patients
| Covariates | Univariate analysis, HR (95% CI) | P value | Multivariate Analysis, HR (95% CI) | P value |
|---|---|---|---|---|
| A3F, per increase of 1 unit | 2.168 (0.868-5.417) | 0.098 | 3.383 (1.249-9.715) | 0.017 |
| A3G, per increase of 1 unit | 0.455 (0.237-0.874) | 0.018 | ||
| A3H, per increase of 1 unit | 0.273 (0.106-0.704) | 0.007 | 0.25 (0.098-0.636) | 0.004 |
| HBV infection (yes vs. no) | 1.782 (1.159-2.739) | 0.008 | ||
| Cirrhosis (yes vs. no) | 1.691 (1.224-2.336) | 0.001 | 1.838 (1.308-2.583) | <0.001 |
| Age, per increase of 1 year | 0.981 (0.966-0.996) | 0.016 | ||
| Tumor size, per increase of 1 cm | 1.129 (1.082-1.177) | <0.001 | 1.095 (1.042-1.15) | <0.001 |
| AJCC stage, per increase 1 stage | 1.944 (1.601-2.36) | <0.001 | ||
| BCLC stage, per increase 1 stage | 1.907 (1.467-2.479) | <0.001 | ||
| Vascular invasion (yes vs. no) | 2.324 (1.662-3.251) | <0.001 | ||
| Intrahepatic metastasis (yes vs. no) | 5.059 (3.528-7.254) | <0.001 | 3.669 (2.447-5.5) | <0.001 |
| AFP (>200 ng/ml vs. <200 ng/ml) | 1.66 (1.198-2.298) | 0.002 |