Table 2.
Genotype distributions of IL-1β +3954 C/T, IL-1β -511 C/T, IL-8-251T/A, IL-10-1082A/G and IL-10-819C/T in CAD patients and controls and their association with CAD risk
| CAD cases | % | Controls | % | OR (95% CI)1 (Multivariate analysis) | P value | |
|---|---|---|---|---|---|---|
| IL-1β +3954 C/T | ||||||
| CC | 217 | 66.77 | 244 | 71.35 | 1.0 (Ref.) | 1 |
| CT | 72 | 22.15 | 70 | 20.47 | 1.16 (0.78-1.71) | 0.45 |
| TT | 36 | 11.08 | 28 | 8.19 | 1.45 (0.83-2.55) | 0.17 |
| CT+TT | 108 | 33.23 | 98 | 28.65 | 1.24 (0.88-1.75) | 0.2 |
| IL-1β -511 C/T | ||||||
| GG | 95 | 29.23 | 114 | 33.33 | 1.0 (Ref.) | 1 |
| GA | 152 | 46.77 | 155 | 45.32 | 1.18 (0.81-1.70) | 0.37 |
| AA | 78 | 24.00 | 73 | 21.35 | 1.28 (0.82-1.99) | 0.24 |
| GA+AA | 230 | 70.77 | 228 | 66.67 | 1.21 (0.86-1.70) | 0.25 |
| IL-8-251T/A | ||||||
| TT | 85 | 26.15 | 108 | 31.58 | 1.0 (Ref.) | 1 |
| TA | 147 | 45.23 | 149 | 43.57 | 1.25 (0.86-1.84) | 0.22 |
| AA | 93 | 28.62 | 85 | 24.85 | 1.39 (0.90-2.14) | 0.11 |
| TA+AA | 240 | 73.85 | 234 | 68.42 | 1.30 (0.92-1.85) | 0.12 |
| IL-10-1082A/G | ||||||
| AA | 138 | 42.46 | 183 | 53.51 | 1.0 (Ref.) | 1 |
| AG | 123 | 37.85 | 119 | 34.80 | 1.37 (0.97-1.94) | 0.06 |
| GG | 64 | 19.69 | 40 | 11.70 | 2.12 (1.32-3.43) | 0.001 |
| AG+GG | 187 | 57.54 | 159 | 46.49 | 1.56 (1.14-2.14) | 0.004 |
| IL-10-819C/T | ||||||
| CC | 115 | 35.38 | 135 | 39.47 | 1.0 (Ref.) | 1 |
| CT | 144 | 44.31 | 143 | 41.81 | 1.18 (0.83-1.68) | 0.33 |
| TT | 66 | 20.31 | 64 | 18.71 | 1.21 (0.77-1.89) | 0.38 |
| CT+TT | 210 | 64.62 | 207 | 60.53 | 1.19 (0.86-1.65) | 0.28 |
1
Adjusted for sex, age, hypertension, diabetes, tobacco smoking and alcohol drinking.