Table 2.
Genotype and allele distribution of ART gene SNPs in infertile patients and fertile controls
| SNP | Genotype | All subjects (N=571) | Control (N=250) | Patients (N=321) | P Value | OR (95% CI) |
|---|---|---|---|---|---|---|
| rs11097230 | AA | 195 (34.2%) | 90 (36%) | 105(32.7%) | -- | -- |
| AG | 276 (48.3%) | 120 (48%) | 156 (48.6%) | 0.565 | 1.134 (0.888-1.448) | |
| GG | 100 (17.5%) | 40 (16%) | 60 (18.7%) | 0.314 | 1.114 (0.771-1.611) | |
| A allele | 666 (58.3%) | 300 (60%) | 366 (57%) | -- | -- | |
| G allele | 476 (41.7%) | 200 (40%) | 276 (43%) | 0.309 | 1.131 (0.892-1.434) | |
| rs17001385 | CC | 204 (35.7%) | 96 (38.4%) | 108 (33.6%) | -- | -- |
| CG | 275 (48.2%) | 119 (47.6%) | 156 (48.6%) | 0.410 | 1.165 (0.810-1.677) | |
| GG | 92 (16.1%) | 35 (14%) | 57 (17.8%) | 0.148 | 1.203 (0.936-1.547) | |
| C allele | 679 (59.5%) | 307 (61.4%) | 372 (57.9%) | -- | -- | |
| G allele | 463 (40.5%) | 193 (38.6%) | 270 (42.1%) | 0.238 | 1.155 (0.909-1.466) | |
| rs6836703 | GG | 222 (38.9%) | 84 (33.6%) | 138 (42.9%) | -- | -- |
| AG | 253 (43.8%) | 128 (51.2%) | 133 (41.4%) | 0.013 | 0.632 (0.440-0.910) | |
| AA | 88 (15.4%) | 38 (15.2%) | 50 (15.57%) | 0.385 | 0.895 (0.696-1.150) | |
| G allele | 705 (61.8%) | 296 (59.2%) | 409 (63.7%) | -- | -- | |
| A allele | 437 (38.3%) | 204 (40.8%) | 233 (36.3%) | 0.120 | 0.827 (0.650-1.051) | |
| rs14773 | AA | 167 (29.2%) | 69 (27.6%) | 98 (30.5%) | -- | -- |
| AC | 300 (52.5%) | 134 (53.6%) | 166 (51.7%) | 0.484 | 0.872 (0.595-1.279) | |
| CC | 104 (18.2%) | 47 (18.8%) | 57 (17.8%) | 0.531 | 0.924 (0.722-1.183) | |
| A allele | 634 (55.5%) | 272 (54.4%) | 362 (56.4%) | -- | -- | |
| C allele | 508 (44.5%) | 228 (45.6%) | 280 (43.6%) | 0.503 | 0.923 (0.729-1.167) |
Values are frequency (no. of individuals). The number of alleles is based on the genotype. The bold entries emphasize that P value <0.05.